Product Information
An important mediator of platelet activation and aggregation is ADP (adenosine 5'-disphosphate) which is released from blood platelets in the vasculature upon activation by various agents, such as collagen and thrombin, and from damaged blood cells, endothelium or tissues. Activation by ADP results in the recruitment of more platelets and stabilisation of existing platelet aggregates. Platelet ADP receptors mediating aggregation are activated by ADP and some of its derivitives and antagonised by ATP (adenosine 5' - triphosphate) and some of its derivatives. Therefore, platelet ADP receptors are members of the family of P2 receptors activated by purine and/ or pyrimidine nucleotides.
A lyophilised preperation of 0.2mM ADP with buffer and stabilisers
